Research Explorer

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Project

Targeting NLRP3-mediated inflammation with novel chemotypes

Outputs & Impact

Publications & research data ( 9 )

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

Muralikrishna AkulaElisabeth GilisPieter HertensLieselotte Vande WalleMozes SzeJulie CoudenysYunus IncikOmar KhanMartin O. BergoDirk Elewaut et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology

Ine PaesmansKristof Van KolenMarc VandermeerenPei-Yu ShihDirk WuytsFleur BooneSergio Garcia SanchezKarolien GrauwenFilip Van HauwermeirenNina Van Opdenbosch et al.

A1 Journal Article in FRONTIERS IN AGING NEUROSCIENCE

Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency

Lieselotte Vande WalleMadhukar SaidOonagh PaerewijckArinna BertoniMarco GattornoBruno LinclauMohamed Lamkanfi

A1 Journal Article in LIFE SCIENCE ALLIANCE

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Drugging the NLRP3 inflammasome : from signalling mechanisms to therapeutic targets

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

Regulated cell death in neutrophils : from apoptosis to NETosis and pyroptosis

Léonie DejasKarin SantoniEtienne MeunierMohamed Lamkanfi

A1 Journal Article in SEMINARS IN IMMUNOLOGY

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Comment on : effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in RHEUMATOLOGY

Activities ( 0 )

Results

Impact narratives ( 1 )

Medicine: immunity and inflammation

Area(s): Health

Patents ( 0 )