01 March 2023 → 29 February 2024
Regional and community funding: Special Research Fund
Medical and health sciences
Hematology TET2 epigenetics T-cell lymphocytes DNA methylation stem cells leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a rare but aggressive subtype of leukemia. During the malignant transformation of T-cells, a clonal expansion of immature cells is selected via the gradual accumulation of advantageous epigenetic changes and genetic mutations. In this project, we investigate the role of the epigenetic regulator, TET2, and DNA demethylation in T-ALL development.