Code
01CD8622
Duration
01 March 2023 → 29 February 2024
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Epigenetics
- Epigenetics
-
Medical and health sciences
- Hematology
Keywords
Hematology
TET2
epigenetics
T-cell lymphocytes
DNA methylation
stem cells
leukemia
Project description
T-cell acute lymphoblastic leukemia (T-ALL) is a rare but aggressive subtype of leukemia. During the malignant transformation of T-cells, a clonal expansion of immature cells is selected via the gradual accumulation of advantageous epigenetic changes and genetic mutations. In this project, we investigate the role of the epigenetic regulator, TET2, and DNA demethylation in T-ALL development.