Project

Cargo identification and dynamic organization of the plant-specific TPLATE endocytic complex and its interplay with AP2

Code

3G009415

Duration

01 January 2015 → 31 December 2020

Funding

Research Foundation - Flanders (FWO)

Promotor

Geert De Jaeger

Research disciplines

Natural sciences
- Regulation of metabolism
- Intracellular compartments and transport
- Plant genetics

Keywords

clathrin-mediated endocytosis plant cell biology protein complex purification TPLATE complex

Project description

We recently identified the TPLATE complex as an essential endocytic complex driving plant clathrin-mediated endocytosis in plants alongside the evolutionary conserved AP-2 complex. Aim of this project is to link membrane proteins to either the TPLATE or the AP-2 complex and to further unravel the function of the TPLATE complex. This will be achieved using proximity biotinylation and conditional delocalization.