Brain function is largely driven by the diverse properties of neurons. But what makes our neurons human?
In this project, we will tackle this question by deciphering the intrinsic and extrinsic mechanisms that shape
the human-specific identity of neurons of the cerebral cortex, with a focus on the gene regulatory
mechanisms that drive human cortical neuron identity, evolution and development. We will push the
boundaries of novel AI-based hypothesis generation, complemented by innovative experimental models
(e.g. humanized mice) to identify the core human-specific regulatory features underlying cortical neuron
identity and their developmental origin. Our highly multidisciplinary approach will establish a new
framework for biological discovery based on iterative data generation, AI-based modeling and subsequent
functional validation using innovative human and mouse experimental systems. It will shed new light on the
molecular underpinnings of human neuronal evolution and its functional consequences, with important
implications for our understanding of human brain function and dysfunction.