Code
01C05420
Duration
15 April 2020 → 14 April 2021
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
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Natural sciences
- Genetic predisposition
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Medical and health sciences
- Immunogenetics
- Innate immunity
- Clinical genetics and molecular diagnostics
- Medical transcriptomics
Keywords
Severe COVID-19
inborn errors of immunity
immunophenotypical characteristics
Project description
This prospective, multidisciplinary and multicentric study aims to gain insights into genetic defects, immunological pathways, and expression shifts that may render some individuals more prone to severe COVID-19. Integrated multi-omics analysis will be used to identify critical host genes and
pathways involved in the infectious process and pathophysiological mechanisms in previously healthy young individuals with severe COVID-19.