Research Explorer

Project

The glyoxylate cycle: a key metabolic path that extends lifespan in caenorhabditis elegans.
Acronym
glyoxylaatcyclus
Code
3G0D6414
Duration
01 January 2014 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • General biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
glyoxylate cycle C. elegans longevity ageing
 
Project description
 

The glyoxylate cycle allows fat-to-sugar conversion in the nematode C. elegans and is necessary for its lifespan extension. We will study the glyoxylate cycle enzymes icl-1 and C08F11.14 in detail by looking at their expression dynamics and localization, checking their role in fat-to-sugar conversion and stress response, and the molecular mechanisms of lifespan extension via the synthesis of protective sugars.