Research Explorer

Project

Disruption of cis-regulatory control as a cause of human genetic disease
Code
01N05510
Duration
01 February 2010 → 30 November 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
Keywords
developmental disorders cis-ruption long-range genetic defect disruption of cis-regulatory control
 
Project description
 

Disruption of cis-regulatory control can lead to altered gene expression and disease as a result of the dissociation of a gene and its cis-regulatory sequences. Through identification of long-range genetic rearrangements in specific developmental conditions and the mapping and functional study of the cis-elements of their corresponding disease genes, we aim at a better insight in the contribution of cis-ruption mechanisms in the molecular pathogenesis of genetic disorders.