Project

Impact of stromal cells of different lymphoid tissues on the replication of feline immunodeficiency virus in monocytic cells and T-lymphocytes

Duration
15 October 2015 → 03 October 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
feline immunodeficiency virus
 
Project description

FIV is an important cat pathogen that causes a lifelong infection. Recently, it was shown that lymphoid tissues are sites of productive viral replication, while replication is silenced in blood. In this project, stromal cells from different lymphoid tissues (lymph nodes, bone marrow, spleen) will be isolated and immortalized and their positive effect on FIV replication in monocytic cells and T-lymphocytes will be examined.