Project

The role of peroxisomes in inflammation and cell death

Duration
01 January 2014 → 31 October 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Dermatology
    • Immunology
    • Otorhinolaryngology
    • Respiratory medicine
    • Dermatology
    • Immunology
    • Otorhinolaryngology
    • Respiratory medicine
    • Speech, language and hearing sciences
    • Dermatology
    • Immunology
    • Otorhinolaryngology
    • Respiratory medicine
Keywords
skin peroxisomes cell death inflammation asthma
 
Project description

The overall goal of this project is to analyze whether cell death, airway and skin inflammation are regulated by the modulation of peroxisomal function.The role of peroxisomes in airway inflammation and in skin will be analyzed in

mice lacking peroxisomal b-oxidation (MFP2-/- mice) and using different conditional knocouts of Pex5 and MFP2. The results of the study will be validated using clinical samples.