Code
01G01914
Duration
01 January 2014 → 31 October 2019
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Dermatology
- Immunology
- Otorhinolaryngology
- Respiratory medicine
- Dermatology
- Immunology
- Otorhinolaryngology
- Respiratory medicine
- Speech, language and hearing sciences
- Dermatology
- Immunology
- Otorhinolaryngology
- Respiratory medicine
Keywords
skin
peroxisomes
cell death
inflammation
asthma
Project description
The overall goal of this project is to analyze whether cell death, airway and skin inflammation are regulated by the modulation of peroxisomal function.The role of peroxisomes in airway inflammation and in skin will be analyzed in
mice lacking peroxisomal b-oxidation (MFP2-/- mice) and using different conditional knocouts of Pex5 and MFP2. The results of the study will be validated using clinical samples.