Research Explorer

Project

Enhanced self-amplifying RNA with prolonged protein production and reduced side-effects.
Code
01CD05524
Duration
01 November 2024 → 30 June 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Transcription and translation
  • Medical and health sciences
    • Non-clinical studies
    • Molecular medicine
    • Biopharmaceuticals
    • Vaccines
Keywords
prolonged duration of action reduced side-effects protein therapy Self-amplifying RNA
 
Project description
A family of enhanced self-amplifying (sa) RNAs was discovered in this research. The enhanced saRNAs demonstrated prolonged activity up to 21 weeks after injection in mice, which is remarkable longer than the current expression time of 4-8 weeks. Additionally, the enhanced saRNAs cause less side-effects. Recognizing the valorization-potential, a patent was recently filed (EP24157148.8), which requires continued validation during the priority-year.