Growth failure is accepted as the most important outcome parameter in childhood chronic kidney disease (CKD), owing to its close relation to mortality. We found that protein-bound uremic toxins (PBUTs) associates with growth failure. As PBUTs are known contributors of the chronic pro-inflammatory state present in CKD, we hypothesize that PBUTs-driven inflammation plays a key role in the pathophysiology of CKD-related growth failure. We aim to (1) identify the key inflammatory pathways, driven by PBUTs, that contribute to CKD-related growth failure and (2) develop a CKD zebrafish model with CKD-relevant outcomes for high throughput screening of therapeutic targets that can mitigate PBUTs-driven inflammatory pathways. This project will be of high relevance for our society, as CKD is a highly prevalent disease with a significant burden and mortality.