Research Explorer

Project

Depressed Skull fractures: Timing of surgery, systemic inflammatory response, surgical site infection, and post-traumatic seizures - (DESTINE Study)
Code
01CD11324
Duration
11 September 2024 → 10 January 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Neurosurgery
Keywords
surgical site infection timing of surgery systemic inflammatory responses Depressed skull fracture post-traumatic epilepsy
 
Project description
 The timing for surgery of depressed skull fracture (DSF) in low-income countries remains unclear due to the risks from intraoperative bleeding versus surgical site infection. Neuro-inflammation induced by trauma, anesthesia, and surgery stress predispose patients to late post-traumatic epilepsy. In-depth immunological, imaging, and clinical studies of patients with DSF could improve the understanding and decision-making of the surgical timing.