Project

Advanced cardiovascular phenotyping of zebrafish models at adult stages: from imaging to fluid dynamics modelling

Code
01CD2822
Duration
24 September 2022 → 23 March 2023
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Cardiac and vascular medicine not elsewhere classified
  • Engineering and technology
    • Biofluid mechanics
Keywords
fluid-structure interaction imaging cardiovascular zebrafish animal models computer modelling fluid dynamics
 
Project description

This interdisciplinary project combines know-how in life sciences and engineering. Experimental data (ultrasound imaging, synchrotron X-ray tomography) is used to develop novel fluid dynamics models for blood flow in adult zebrafish. The application of these models in zebrafish strains carrying engineered genetic mutations that lead to cardiovascular abnormalities, allows to assess the impact of genetic mutations on advanced hemodynamic parameters.