Project

Advanced cardiovascular phenotyping of zebrafish models at adult stages: from imaging to fluid dynamics modelling

Code

01CD2822

Looptijd

24-09-2022 → 23-03-2023

Financiering

Regional and community funding: Special Research Fund

Promotor

Patrick Segers

Fellow

Matthias Van Impe

Onderzoeksdisciplines

Medical and health sciences
- Cardiac and vascular medicine not elsewhere classified
Engineering and technology
- Biofluid mechanics

Trefwoorden

cardiovasculair diermodellen vloeistof-structuur interactie computermodellen vloeistofdynamica zebravis beeldvorming

Projectomschrijving

This interdisciplinary project combines know-how in life sciences and engineering. Experimental data (ultrasound imaging, synchrotron X-ray tomography…) is used to develop novel fluid dynamics models for blood flow in adult zebrafish. The application of these models in zebrafish strains carrying engineered genetic mutations that lead to cardiovascular abnormalities, allows to assess the impact of genetic mutations on advanced hemodynamic parameters.