Project

Inhibiting nef: a novel drug target for HIV-drug interactions

Acronym
iNEF
Code
41N00108
Duration
01 January 2008 → 31 May 2013
Funding
European funding: framework programme
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
small molecule inhibitor nef HIV
 
Project description

Efficacy of anti-retroviral therapy in HIV infected people is limited by the appearance of drug resistence. Non-enzyme drug targets need to be probed as alternative viral inhibition. The HIV Nef protein, shown to be an important determinant for in vivo pathogenicity, will be studied in this project as such a potential drug target for HIV host interactions.