The BOF basic funding will mainly be used for the temporary financing of new/finalizing PhD students and non-statutory supporting staff, primarily within the broader subject of "the omics of aging." Three related research lines are being developed for this purpose: allele-specific gene expression, epigenetic clocks, and protein clocks. Epigenetic clocks and protein clocks are trained on omics datasets using machine learning to measure biological age. The basic idea is that biological age is a better indicator of aging (and risk of death) than chronological age, and thus potentially useful in preventing aging-related diseases. In addition, we attempt to gain insight into the underlying mechanisms of aging, for example, by examining whether the disruption of interesting genes (e.g., inferred from the clocks) is biallelic ("faulty reprogramming") or monoallelic ("random errors") in relation to aging.