Research Explorer

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Project

ILM photodisruption: a biophotonic approach to promote retinal ganglion cell engraftment as a cure for blindness

Outputs & Impact

Publications & research data ( 7 )

Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells

Emma De CosterKaat De ClerckChloë De ClercqWeiran LiDeep PunjBernd VanmeerhaegheJonie VerdonckStefaan De SmedtKevin BraeckmansHanieh Hadady et al.

A1 Journal Article in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Overcoming size barriers in retinal gene therapy via lipid nanoparticle-mediated delivery of full-length eys DNA

Sarah GoddaerEmma De CosterElise CallensEmma Van CaenegemOlivier Van den HeuleRob W. J. CollinKaren PeynshaertFilip Van NieuwerburghKevin BraeckmansKatrien Remaut

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye

Weiran LiHelena VanlucheneLaura RaesKaren PeynshaertLiene VeysSofía González HernándezEmily De LombaerdeBruno De GeestNiek SandersLieve Moons et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption

Kaat De ClerckEmma De CosterLuca PaolettiStefaan De SmedtKatrien RemautKaren Peynshaert

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

Toward successful retinal drug delivery after intravitreal injection : current strategies to overcome the inner limiting membrane

Kaat De ClerckStefaan De SmedtKatrien RemautKaren Peynshaert

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells

Helena VanlucheneOriane GillonKaren PeynshaertStefaan De SmedtNiek SandersKoen RaemdonckKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Every nano-step counts : a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy

Karen PeynshaertJoke DevoldereStefaan De SmedtKatrien Remaut

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )