Code
3GP02807
Duration
01 February 2007 → 30 January 2010
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Organic chemistry
- Other chemical sciences
-
Agricultural and food sciences
- Agricultural plant production
Keywords
quinones
pentalongin
aza-antraquinones
mollugin
Project description
Synthesis of nitrogen analogues of naturally occurring pyranonaphtopquinones, 2-aza-antraquinones en related compounds. Asymmetric synthesis of target compounds (trans-dihydroxymollugin viaepoxides, cis-dihydroxymollugin and isagarin via asymmetric dihydroxylation). Oxidation protocols based on cerium(IV) ammonium nitrate. Bio-activity tests, screening for antifungal and antitubercular activities.