Project

Characterization of the unique molecular network that controls T cell development.

Duration
01 October 2013 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
transcription factors Notch Signaling T-cell diferentiation hematopoietic stem cells
 
Project description

T-lymphocytes are derived from hematopoietic stem cells and their differentiation depends on the integration of multiple transcriptional regulators such as GATA3, TCF1, BCL11B and Notch signaling. The kinetics and expression levels of these factors are critical for T-cell development. In this project, we wish to investigate how these factors

interact to modulate downstream gene expression during normal human T-cell development.