Project

Structural biology of Interleukin-34, a novel cytokine ligand for colony stimulating factor 1 receptor (CSF-1R)

Duration
01 October 2011 → 30 September 2015
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analysis
    • Medicinal and biomolecular chemistry
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
Keywords
IL34 IL34CSF1R interaction
 
Project description

We propose an interdisciplinary research project at the frontline of molecular structural biology to dissect the interaction of a novel cytokine, interleukin 34, with its hematopoietic RTKIII receptor, Colony Stimulating Factor1 Receptor. The proposed research project aims to elucidate the structural, kinetic and thermodynamic determinants that dictate this unusual cytokinereceptor specificity, using both experimental and computational methods in structural biology.