Project

Dissection of the molecular basis of bacterial type II secretion in pathogenic bacteria

Duration
01 January 2010 → 31 October 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Condensed matter physics and nanophysics
    • Medicinal and biomolecular chemistry
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
Keywords
proteomics bacterial pathogenesis structural biology bacterial secretion mass-spectrometry
 
Project description

The process of bacterial secretion is integral to the life cycle of bacteria and the virulence of pathogenic bacteria. Under the umbrella of this funding initiative, we propose an interdisciplinary research program at the interface of biochemistry, microbiology, structural biology and biophysics to dissect the molecular basis of type II secretion in two most important opportunistic human pathogens: Pseudomonas aeruginosa and Burkholderia cenocepacia.