Project

Pathogenesis of chronic obstructive pulmonary disease (COPD): Role of cigarette smoke-induced macrophage reprogramming and the chemokine receptor-mediated adaptive immune response in an experimental COPD model

Duration
01 October 2008 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Respiratory medicine
    • Respiratory medicine
    • Respiratory medicine
Keywords
innate imprinting macrophage DC smoke CCR7 COPD corticosteroid resistance
 
Project description

Investigate cigarette smoke-induced macrophage reprogramming, which may be responsible for corticosteroid resistance in COPD patients. This innate imprinting can also neutralize the macrophage-mediated suppression of DC-function and -migration and contribute to the adaptive immune response in COPD. The adaptive immune response (including lymphoid neogenesis) will be further investigated using CCR7 deficient mice