Research Explorer

Project

Pathogenesis of chronic obstructive pulmonary disease (COPD): Role of cigarette smoke-induced macrophage reprogramming and the chemokine receptor-mediated adaptive immune response in an experimental COPD model
Code
3E001008
Looptijd
01-10-2008 → 30-09-2014
Financiering
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Onderzoeksdisciplines
  • Medical and health sciences
    • Respiratory medicine
    • Respiratory medicine
    • Respiratory medicine
Trefwoorden
corticosteroïd resistentie macrofaag COPD DC innate imprinting rook CCR7
 
Projectomschrijving

Investigate cigarette smoke-induced macrophage reprogramming, which may be responsible for corticosteroid resistance in COPD patients. This innate imprinting can also neutralize the macrophage-mediated suppression of DC-function and -migration and contribute to the adaptive immune response in COPD. The adaptive immune response (including lymphoid neogenesis) will be further investigated using CCR7 deficient mice