Project

QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds

Duration
01 October 2008 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
synthesis flavonoïds anti-invasive agents chalcones QSAR
 
Project description

Invasion and metastasis are the foremost causes of the fatal outcome of cancer and accordingly pose a main challenge in oncology. Using a predictive QSAR-model as a rationale and an in vitro assay as verification, the objective of this project is to synthesise new potent anti-invasive agents amongst the classes of chalcones and related heterocyclic compounds.