Project

A profound study of the anti-inflammatory condition of the mouse strain SPRET/Ei, with emphasis on the glucocorticoidreceptor and the X chromosome

Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • General biology
  • Medical and health sciences
    • Immunology
    • Immunology
    • Microbiology
    • Immunology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
glucocorticoid receptor LPS and SPRET/Ei
 
Project description

The LPS-resistance of SPRET/Ei is genetically linked to chromosomes 2 and X, and dependent on higher glucocortiod receptor expression levels. We want to search for the basis of this higher expression, and the relation with the loci on chromosomes 2 and X. We also want to study the X-locus in more detail, to possibly identify a protecting gene.