Code
01D21621
Duration
01 October 2021 → 31 October 2022
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Cancer therapy
- Medical biochemistry and metabolism not elsewhere classified
- In vitro testing
- Medicinal products not elsewhere classified
Keywords
Curcumin(oid) selectivity
Colon cancer in vitro model
Intracellular accumulation and metabolism (bioavailability)
Project description
In this project, curcumin analogues, synthesized to improve curcumin’s stability, bioavailability and anticancer selectivity, will be investigated on novel 3D cell models for colon cancer by examining accumulation, biotransformation and -activity using microscopic, analytical and cellular-molecular techniques, followed by in vivo validation. The new compounds and mechanistic insights may open perspectives for product development in food (supplement) and pharma industry.