Research Explorer

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Project

The role of macrophages in the pathogenesis of diseases with an affected gut-liver axis

Outputs and Outcomes

Code

01N12119

Duration

01 June 2019 → 31 March 2024

Funding

Regional and community funding: Special Research Fund

Promotor

Lindsey Devisscher

Research disciplines

Medical and health sciences
- Immunology not elsewhere classified
- Gastro-enterology and hepatology not elsewhere classified

Keywords

Gut-liver axis macrophages chronic liver disease

Project description

The liver and the gut are anatomically and functionally interconnected via the enterohepatic and portal circulation (gut-liver axis). Intriguingly, chronic liver disease is characterized by increased gut permeability (leaky gut) which contributes to further disease development. Here, we wish to unravel
the role of macrophages, innate immune cells, in the gut-liver axis in chronic liver diseases with concomitant gut inflammation.

English

Dutch

English

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