Application of halogenated β-lactams for the stereoselective synthesis of novel mono-, bi- and tricyclic nitrogen compounds

01 October 2009 → 30 September 2013
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
stereoselectivity azaheterocycles β-lactams
Project description

This research project aims at the preparation and stereoselective transformation of (chiral) β-lactams bearing halogenated side chains and/or β-lactams bearing aa chloro atom into biologically relevant mono-, bi- and tricyclic nitrogen compounds such as new tricyclic β-lactams and bis-aziridines. Furthermore, the development of novel entries into piperidin-3-ones and azetidin-3-ones from 4-(2-bromo-1,1-dimethoxy)-β-lactams will be studied.