Project

NaV1.9 regulation of itch

Duration
15 April 2019 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
  • Medical and health sciences
    • Physiological biophysics
    • Neurophysiology
Keywords
NaV1.9 itch pruritus sodium channel genetics
 
Project description

Patients with mutations in voltage-gated sodium (NaV) channels report a dramatic increase in itch. We seek to understand the role of NaV1.9 in transmitting itch signals from the skin to the spinal cord. Completion of our goals will offer a starting point to explain the mechanism underlying NaV channel mutations that cause pathological itch, a necessary step to design therapeutics.