Code
01N10819
Duration
15 April 2019 → 14 April 2025
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics
-
Medical and health sciences
- Physiological biophysics
- Neurophysiology
Keywords
NaV1.9
itch
pruritus
sodium channel
genetics
Project description
Patients with mutations in voltage-gated sodium (NaV) channels report a dramatic increase in itch. We seek to understand the role of NaV1.9 in transmitting itch signals from the skin to the spinal cord. Completion of our goals will offer a starting point to explain the mechanism underlying NaV channel mutations that cause pathological itch, a necessary step to design therapeutics.