Project

Precision genomics in neurodegenerative brain disease: from patients to small model organisms and single cells

Duration
15 April 2019 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Clinical genetics and molecular diagnostics
Keywords
neurogenetics neurodegeneration
 
Project description

We will study genomic aspects of rare neurodegenerative brain disorders (NBD). First, we will establish a multidisciplinary clinical neurogenetics program at UZ Gent. Second, we will use fruit flies to study the potential pathogenic nature of novel NBD-related genetic variants. Third, we will use single-cell sequencing to study the role of genomic mosaicism in neurodegeneration.