Project

An integrated approach towards understanding and treating soft tissue mineralization, with pseudoxanthoma elasticum as a model.

Duration
01 January 2015 → 31 October 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Pediatrics and neonatology
    • Pediatrics and neonatology
    • Nursing
    • Pediatrics and neonatology
Keywords
soft tissue mineralization
 
Project description

We aim to advance the understanding of soft tissue mineralization pathophysiology and treatment using pseudoxanthoma elasticum as a model. First, we aim to clarify cellular mechanisms underlying calcification. Second, we will address phenotypic variability in mineralization disorders by identifying modifier genes using Next Generation Sequencing. Third, we will identify human biomarkers and perform screening of therapeutic compounds in zebrafish models.