Research Explorer

Project

Glyco-engineering of IL-10 and IL-22 for tissue-specific delivery via lectin receptors
Code
178WE0210
Duration
01 October 2009 → 26 February 2015
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism not elsewhere classified
  • Medical and health sciences
    • Medical biochemistry and metabolism not elsewhere classified
    • Medical biochemistry and metabolism not elsewhere classified
    • Medical biochemistry and metabolism not elsewhere classified
Keywords
IL-22 glyco-engineering IL-10
 
Project description
 

The aim of this PhD project is to develop specific glycoforms of potentially therapeutic cytokines (hIL-10 and hIL-22). We want to investigate in vivo whether specific glycoforms of the cytokines are excited in specific organs through binding with 
tissue-specific lectins. Our focus here includes interactions with the asialoglycoprotein receptor (ASGP-R). Ultimately, we want to investigate whether this physical enrichment actually leads to increased local cytokine activity. In this way we aim to develop a new experimental therapy for chronic liver disease.