Research Explorer

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Project

Understanding the evolutionary dynamics of phage lysin configurations as a driver for new enzyme-based antibiotics

Outputs & Impact

Publications & research data ( 14 )

SPAED : harnessing AlphaFold output for accurate segmentation of phage endolysin domains

Alexandre BoulayEmma CremelieClovis GaliezYves BriersElsa RousseauRoberto Vázquez

A1 Journal Article in BIOINFORMATICS

Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins

Roberto VázquezDiana Gutierrez FernandezBjorn CrielZoë DezutterYves Briers

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Understanding the role of amidase domains in bicatalytic staphylococcal endolysins

Seila AgúnRoberto VázquezLucía FernándezPilar GarcíaYves Briers

PhaLP 2.0 : a community-oriented database and portal for phage lysin research with new tailored computational tools and metagenomic data

Roberto VázquezAlexandre BoulayVictor NémethEmma CremelieBjorn CrielClovis GaliezElsa RousseauYves Briers

‘Exquisite specificity’, if the context allows : endolysin evolution is a contingent outcome of phage-host molecular landscapes

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielDennis GrimonRémy GoudeseuneJuan Roque Lizasoain VallejoSeila AgúnYves Briers

The new SH3b_T domain increases the structural and functional variability among SH3b-like CBDs from staphylococcal phage endolysins

Roberto VázquezDiana Gutierrez FernandezDennis GrimonLucía FernándezPilar GarcíaAna RodríguezYves Briers

A1 Journal Article in PROBIOTICS AND ANTIMICROBIAL PROTEINS

A comparative guide to expression systems for phage lysin production

Emma CremelieRoberto VázquezYves Briers

A1 Journal Article in ESSAYS IN BIOCHEMISTRY

Lessons learned from a systematic structural-functional characterization of cell wall binding domains (CBDs) from phage endolysins

Roberto VázquezDiana Gutierrez FernandezZoë de ZutterBjorn CrielYves Briers

Phage lysins for intestinal microbiome modulation : current challenges and enabling techniques

Iris PottieRoberto VázquezTom Van de WieleYves Briers

A1 Journal Article in GUT MICROBES

You get what you test for : the killing effect of phage lysins is highly dependent on buffer tonicity and ionic strength

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielPhilippe De GrooteYves Briers

A1 Journal Article in MICROBIAL BIOTECHNOLOGY

Structural and functional diversity of staphylococcal cell wall binding domains

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielYves Briers

Structural and functional diversity of cell wall binding domains in staphylococcal endolysins

Roberto VázquezDiana Gutierrez FernandezBjorn CrielAna RodríguezPilar GarcíaYves Briers

Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria

Hans GerstmansLisa DuyvejonckRoberto VázquezInes StaesJimmy BorlooKarim Abdelkader Soufi AbdelkaderJeroen LeroyEmma CremelieDiana Gutierrez FernandezHéctor Tamés-Caunedo et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM

What's in a name? An overview of the proliferating nomenclature in the field of phage lysins

Roberto VázquezYves Briers

A1 Journal Article in CELLS

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )