Research Explorer

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Project

Understanding the evolutionary dynamics of phage lysin configurations as a driver for new enzyme-based antibiotics

Outputs and Outcomes

Publications

A comparative guide to expression systems for phage lysin production

Emma CremelieRoberto VázquezYves Briers

A1 Journal Article in ESSAYS IN BIOCHEMISTRY

Lessons learned from a systematic structural-functional characterization of cell wall binding domains (CBDs) from phage endolysins

Roberto VázquezDiana Gutierrez FernandezZoë de ZutterBjorn CrielYves Briers

Phage lysins for intestinal microbiome modulation : current challenges and enabling techniques

Iris PottieRoberto VázquezTom Van de WieleYves Briers

A1 Journal Article in GUT MICROBES

The new SH3b_T domain increases the structural and functional variability among SH3b-like CBDs from staphylococcal phage endolysins

Roberto VázquezDiana Gutierrez FernandezDennis GrimonLucía FernándezPilar GarcíaAna RodríguezYves Briers

A1 Journal Article in PROBIOTICS AND ANTIMICROBIAL PROTEINS

You get what you test for : the killing effect of phage lysins is highly dependent on buffer tonicity and ionic strength

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielPhilippe De GrooteYves Briers

A1 Journal Article in MICROBIAL BIOTECHNOLOGY

Structural and functional diversity of staphylococcal cell wall binding domains

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielYves Briers

Structural and functional diversity of cell wall binding domains in staphylococcal endolysins

Roberto VázquezDiana Gutierrez FernandezBjorn CrielAna RodríguezPilar GarcíaYves Briers

Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria

Hans GerstmansLisa DuyvejonckRoberto VázquezInes StaesJimmy BorlooKarim Abdelkader Soufi AbdelkaderJeroen LeroyEmma CremelieDiana Gutierrez FernandezHéctor Tamés-CaunedoPatricia Ruas-MadiedoAna RodríguezAbram AertsenJeroen LammertynRob LavigneYves Briers et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM