Project

Triple punch against melanoma: photodynamic therapy, immunogenic cell death and photothermal ablation

Code

01G02923

Duration

01 January 2023 → 31 December 2026

Funding

Regional and community funding: Special Research Fund

Promotor-spokesperson

Andre Skirtach

Research disciplines

Natural sciences
- Nanochemistry
- Optical properties of materials
- Chemistry of clusters, colloids and nanomaterials
Medical and health sciences
- Cell death
- Cancer therapy

Keywords

nanothermometers polymers immunotherapy cancer nanoparticles

Project description

The rapid growth of cancer immunotherapy offers a new perspective for designing effective treatments. However, often responses are low since tumours exhibit different resistance mechanisms. This proposal will combine photodynamic therapy with photothermal ablation based on nanocapsules and nanothermometers, aiming to trigger immunogenic cell death and induce efficient anti-tumour immunity. It will improve the efficacy of cancer immunotherapy.