Research Explorer

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Project

Novel mechanisms of inflammation and cell death regulation in autoinflammatory and infectious diseases

Outputs & Impact

Publications & research data ( 25 )

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

Muralikrishna AkulaElisabeth GilisPieter HertensLieselotte Vande WalleMozes SzeJulie CoudenysYunus IncikOmar KhanMartin O. BergoDirk Elewaut et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the TNF pathway

Tom DelangheMike VadiAnnelore HaemsLisa WijnsInge BruggemanJon HuygheDario PriemPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Primidone : a clinically promising candidate for the treatment of psoriasis

Theresa RiebelingBenedikt KolbrinkRebecca PhilippsenEileen DahlkeTom DelangheFranziska TheiligAgatha SchwarzRoland SchmittMathieu BertrandUlrich Kunzendorf et al.

A1 Journal Article in CELL DEATH DISCOVERY

Proximal partners of the organellar N-terminal acetyltransferase NAA60 : insights into Golgi structure and transmembrane protein topology

Sebastian TancoVeronique JonckheereArun Kumar Tharkeshwar RaghunathAnnelies BogaertKris GevaertWim AnneartPetra Van Damme

A1 Journal Article in OPEN BIOLOGY

MAP kinase signaling at the crossroads of inflammasome activation

Alex VervaekeMohamed Lamkanfi

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Maude JansMagdalena KolataGillian BlanckeAline D'HondtClaudia GrafMaarten CiersMozes SzeAlexandra ThiranIoanna PettaVanessa Andries et al.

A1 Journal Article in NATURE

NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology

Ine PaesmansKristof Van KolenMarc VandermeerenPei-Yu ShihDirk WuytsFleur BooneSergio Garcia SanchezKarolien GrauwenFilip Van HauwermeirenNina Van Opdenbosch et al.

A1 Journal Article in FRONTIERS IN AGING NEUROSCIENCE

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

Onay VeliOyku KayaAna Beatriz VarandaXimena HildebrandtPeng XiaoYann EstornesMatea PoggenbergYuan WangManolis PasparakisMathieu Bertrand et al.

A1 Journal Article in MOLECULAR METABOLISM

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

Diego Rojas RiveraSebastián BeltránFrancisco Muñoz-CarvajalPablo Ahumada-MontalvaLorena AbarzúaLaura GomezFernanda HernandezCristian A BergmannLuis LabradorMelissa Calegaro-Nassif et al.

A1 Journal Article in AUTOPHAGY

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Parul MehrotraSophia MaschalidiLaura BoeckaertsChristian MaueröderRochelle TixeiraJonathan PinneyJavier BurgoaVladimir SukhovYunus IncikChristopher Anderson et al.

A1 Journal Article in NATURE

Proteins à la carte : riboproteogenomic exploration of bacterial N-terminal proteoform expression

Igor FijalkowskiValdes SnauwaertPetra Van Damme

A1 Journal Article in MBIO

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Ioanna PettaMarie ThorpMaarten CiersGillian BlanckeLouis BoonTim MeeseFilip Van NieuwerburghAndy WullaertRichard GrencisDirk Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A20 : a jack of all trades

Pieter HertensGeert van Loo

Editorial material

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma

Jelle VerhoevenKathryn A. JacobsFrancesca RizzolloFrancesca LodiYichao HuaJoanna PoźniakAdhithya Narayanan SrinivasanDiede HoubaertGautam ShankarSanket More et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Cell death checkpoints in the TNF pathway

Jon HuygheDario PriemMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars Vereecke et al.

A1 Journal Article in CELL DEATH & DISEASE

Shift in vacuolar to cytosolic regime of infecting Salmonella from a dual proteome perspective

Ursula FelsPatrick WillemsMargaux De MeyerKris GevaertPetra Van Damme

A1 Journal Article in PLOS PATHOGENS

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien EeckhoutLisa HamerlinckVeronique JonckheerePetra Van DammeGeert van LooAndy Wullaert

A1 Journal Article in CELL DEATH & DISEASE

Activities ( 0 )

Results

Impact narratives ( 2 )

Area(s): Health

Medicine: immunity and inflammation

Area(s): Health

Patents ( 0 )