Project

Study of molecular pathogenesis of Ehlers-Danlos syndrome/

Code
3E011909
Duration
01 October 2009 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
 
Project description

EDS is a heteregenous group of heritable disorders of connective tissue. Although mutation in genes encording fibrillar collageens or collagen-modyfying enzymes have been identified in some EDS-subtypes, the molecular basis of a number of other subtypes, such as the classic and the hypermobility type, remain at present poorly explored. This project aims to contribute to the identification of genes involved in different EDS-subtypes using a combination of conventional biochemical and molecular strategies and new, perfomant, high throughput genomic technology, including next genenation sequencing and array-based comparative genome hybridization.