EDS is a heteregenous group of heritable disorders of connective tissue. Although mutation in genes encording fibrillar collageens or collagen-modyfying enzymes have been identified in some EDS-subtypes, the molecular basis of a number of other subtypes, such as the classic and the hypermobility type, remain at present poorly explored. This project aims to contribute to the identification of genes involved in different EDS-subtypes using a combination of conventional biochemical and molecular strategies and new, perfomant, high throughput genomic technology, including next genenation sequencing and array-based comparative genome hybridization.