Code
01J03108
Duration
01 January 2008 → 31 October 2012
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Social sciences
- Biological and physiological psychology
- Cognitive science and intelligent systems
- Developmental psychology and ageing
-
Medical and health sciences
- Laboratory medicine
- Neurosciences
- Orthopaedics
- Laboratory medicine
- Neurosciences
- Orthopaedics
- Laboratory medicine
- Neurosciences
- Orthopaedics
Keywords
NF-kappaB
I-kappaB
chemokines
cytokines
auto-immunity
myopathy
Project description
Sporadic inclusion body myositis (IBM), a subtype of the idiopathic inflammatorymyopathies (IM), is resitant to conventional glucocortidoid therapy. This project focuses on the interactions between the transcription factor NF-kappaB, essential to auto-immunity, and glucocorticoids, in IM and Duchenne muscular dystrophy (DMD). DMD is another auto-immune muscle disease responsive to glucocorticoids, although the degeneration that characterizes IBM muscles, also occurs.