Project

Synthesis and eva luation o f new inhibitors of penicillin-binding proteins from resistant bacteria en route to new antibacterial agents

Duration
01 October 2014 → 01 October 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
Keywords
chemical synthesis beta-lactams
 
Project description

The development of resistance to antibiotics can interfere with, or even prevent, the treatment of bacterial infections, especially in hospitals. This project intends to discover new inhibitors of the penicillin-binding proteins from resistant bacterial strains. Strategies for inhibitor discovery will involve computational techniques, chemical synthesis and structural, biochemical, antimicrobial and toxicological evaluations.