Code
01J19810
Duration
01 May 2010 → 19 September 2013
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Immunology
- Otorhinolaryngology
- Immunology
- Otorhinolaryngology
- Speech, language and hearing sciences
- Immunology
- Otorhinolaryngology
Keywords
inflammation
T regulatory cells
CRS
Project description
In this study, T cell plasticity and survival and the role of different damage-associated molecular patterns, prostaglandins, and bacterial superantigens in chronic rhinosinusitis will be studed. The role of the specific mucosal milieu on T cell plasticity will be analyzed in vitro, in vio in Rag2-/-γc-/- knockout mice transplanted with human inflamed mucosa, and ex vivo in human nasal mucosal tissue.