Project

T-cell plasticity in chronic inflammatory airway diseases.

Duration
01 May 2010 → 19 September 2013
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Otorhinolaryngology
    • Immunology
    • Otorhinolaryngology
    • Speech, language and hearing sciences
    • Immunology
    • Otorhinolaryngology
Keywords
inflammation T regulatory cells CRS
 
Project description

In this study, T cell plasticity and survival and the role of different damage-associated molecular patterns, prostaglandins, and bacterial superantigens in chronic rhinosinusitis will be studed. The role of the specific mucosal milieu on T cell plasticity will be analyzed in vitro, in vio in Rag2-/-γc-/- knockout mice transplanted with human inflamed mucosa, and ex vivo in human nasal mucosal tissue.