Research Explorer

Project

A pre-targeted nanomedicine strategy for in vivo CD8+ T cell engineering.
Code
1121023N
Duration
01 November 2022 → 31 October 2026
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Applied immunology
    • Biopharmaceuticals
    • Pharmaceutical technology
  • Engineering and technology
    • Nanomaterials
Keywords
Immunotherapy Nanotechnology T-cells
 
Project description
 

The goal of this project is to investigate a strategy to pre-target CD8+ T cells in vivo with a chemical moiety that allows for subsequent cellspecific delivery of nanoparticle-formulated therapeutics, functionalized with a complimentary reactive moiety on their surface using ultrafast covalent click chemistry. Via this technology, we aim to modulate T cells in vivo in the blood and in the tumor microenvironment.