Project

Characterisation of ST2/IL-33 signaling and evaluation of the therapeutic potential of nanobody mediated targeting of IL-33

Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Physiology
    • Immunology
    • Medical biochemistry and metabolism
    • Physiology
    • Immunology
    • Medical biochemistry and metabolism
    • Physiology
Keywords
nanobodies interleukin-33 signal transduction therapy
 
Project description

Interleukine-33 (IL-33) is a recently identified cytokine that binds the ST2 receptor and regulates the activity of several cells that are involved in immunity. In this project we will use several molecular biological approaches and mouse models to study the mechanism of action of IL-33 and the therapeutic potential of IL-33 inhibition.