Research Explorer

Project

A mycobacterium bovis BCG transposon insertion library as a tool to study the role of mycobacterial glycolipids and other components in pathogenesis.
Code
31511609
Duration
01 January 2009 → 30 December 2011
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology not elsewhere classified
    • Systems biology not elsewhere classified
  • Medical and health sciences
    • Immunology not elsewhere classified
    • Laboratory medicine not elsewhere classified
    • Microbiology not elsewhere classified
Keywords
Mycobacterium vaccine infection
 
Project description

We aim at improving the protectieve efficacy of the M. bovis BCG vaccine against M.tb infection. We have generated an ordered M. bovis BCG transposon insertion library and selected mutants for further study. These mutants are characterizing biochemically and evaluated as TB vaccines in a stringent animal model. We're thoroughly studying immune responses upon infection, which mainly determine vaccine potential.