Copper (Cu) and Zinc (Zn) are essential micronutrients widely added to animal feed to promote growth and eliminate diseases. However, a significant part of Cu/Zn is excreted and transported to the soil with manure applications, causing Cu and Zn accumulation in soils. Phytoextraction was proposed to be considered as a potential technology to produce Cu/Zn-biofortified alfalfa from Cu/Zn-enriched soils as an alternative for Cu/Zn supplementation. Thus, the integrated technology allowed to recycle Cu/Zn into biomass that can, to an extent, substitute Cu/Zn feed additives, beneficially reducing the abuse of Cu/Zn feed additives and preventing Cu/Zn deficiency.