The project aims at a global and integrated approach of the 4 major types of cell death (apoptosis, necrosis, autophagic cell death, pyroptosis) on four levels: the biochemistry of caspases and RIP kinases, the intracellular signal transduction, the intercellular communication and its role in experimental diseaese models using transgenic animals. We will use global approaches involving shRNA, siRNA and miRNA screenings, interactomics, degradomics, phosphoproteomics and bioinformatics.