This study investigates clinical efficacy and mechanism of action oc continuous Theta Burts Stimulation (cTBS) in epilepsy in a translational design, in an animal model for cortical hyperexcitability and refractory epilepsy patients. We hypothesize that cTBS is an effective anti-epileptic treatment based on demonstrated neuromodulatory effects in preclinical research, decreasing cortical excitability and modulating functional connectivity across the epileptic brain.