Radiotherapy (RT) is one of the treatment modalities for head and neck cancer in 80% of the patients.

Durig a 7-week course of RT, anatomy will change while in standard treatment, there is only 1 imaging before start of RT, leading to overdosage of normal structures and impaired quality of life. 

With adaptive RT (ART) replanning is done based on repeated imaging once or twice during RT. This is labour intensive and still not accurate on daily basis. Online ART allows for adjustment to daily anatomical changes. It is a novel technique that can be administered with an innovative linear accelerator available at UZ Gent. At the moment, there is no evidence about the use of daily ART, its usefulness and its pitfalls. 

With this project we aim at elaborating the above mentioned uncertainties and at redefining existing paradigms in RT-planning as to date, these planning paradigms have always been based on non-ART while this novel technique is expected to be implemented in routine clinics in the near future.