Research Explorer

Project

Evaluation of the flatworm Macrostomum lignano as an in vivo epigenetic model system
Code
01J04913
Duration
01 March 2013 → 31 December 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • General biology
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
platyhelminthes DNA methylation stem cells
 
Project description
 

The global DNA methylation status of the flatworm Macrostatum lignano, the (transgenerational) effect of inhibitors of DNA methyltransferases and histone deacetylases on stem cell dynamics and phenotypic endpoints will be investigated. RNAi will demonstrate what are the specific effects of epigenetic changes in stem cells. Different chemical stubstances will be screened for their epigenetic effects.