Code
01IO4420
Duration
01 October 2020 → 30 September 2024
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Macromolecular and materials chemistry not elsewhere classified
- Organic chemistry not elsewhere classified
-
Medical and health sciences
- Drug discovery and development not elsewhere classified
- Biopharmaceuticals
-
Engineering and technology
- Medical nanotechnology
Keywords
Polymer synthesis
cationic polymers
transfection agent
RNA
therapeutics
Project description
Nowadays, researchers can make synthetic self-amplifying messenger RNAs (sa-mRNAs) that encode for any desired protein. However, these synthetic RNAs require efficient carriers that protect and deliver them inside the cytoplasm of cells. In this project, we aim to develop cationic polymer transfection agents for in vitro and in vivo transfection of synthetic self-amplifying mRNAs.