Cationic polymers with controlled charge separation for non-viral RNA delivery

01 October 2020 → 30 September 2024
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Macromolecular and materials chemistry not elsewhere classified
    • Organic chemistry not elsewhere classified
  • Medical and health sciences
    • Drug discovery and development not elsewhere classified
    • Biopharmaceuticals
  • Engineering and technology
    • Medical nanotechnology
Polymer synthesis cationic polymers transfection agent RNA therapeutics
Project description

Nowadays, researchers can make synthetic self-amplifying messenger RNAs (sa-mRNAs) that encode for any desired protein. However, these synthetic RNAs require efficient carriers that protect and deliver them inside the cytoplasm of cells. In this project, we aim to develop cationic polymer transfection agents for in vitro and in vivo transfection of synthetic self-amplifying mRNAs.