With over 355,000 surgeries each year, rhinoplasties are amongst the most performed facial reconstructive surgeries worldwide. Nasal cartilage defects can be caused by congenital defects, trauma or cancer. Generally, nasal cartilage reconstruction is required to avoid concomitant impairment of breathing. However, current gold standards (autografts and permanent synthetic implants) remain suboptimal. In my PhD, I will exploit tissue engineering as a promising alternative strategy, based on the development of 3D-printed biodegradable, patient-specific synthetic implants exhibiting excellent CAD/CAM mimicry. For this purpose, I will create thiol-ene photo-crosslinkable resins to be applied in volumetric 3D-printing. I will chemically design synthetic networks such that they mimic the mechanical properties (i.e., Young’s modulus 1-30 MPa) of native nasal cartilage and they exhibit a biodegradation time of 10-15 months while ensuring bioactivity. More specifically, their cell-interactivity will promote tissue integration while their antimicrobial properties will exclude infection. For this purpose, I will chemically incorporate cell-interactive and antimicrobial peptides as well as growth factors within the printed constructs via thiol-ene coupling. To this end, thiolated peptides and growth factors will be added to the resins prior to 3D-printing. The printed constructs, based on patient-specific defects, will be evaluated in vitro and in vivo for their biological performance.